Carbon Capture and Storage (CCS) will play a vital role for carbon dioxide (CO2) emissions reduction. Pipelines are considered the preferred method for both onshore and offshore large volumes of CO2 transported. In the Humber region in the UK, there are two advanced proposals for CCS power station developments: the Don Valley project and the White Rose (Drax) CCS project, which were expected to provide a basis to develop a pipeline supporting a CCS cluster in this area. This paper presents a case study of the pipeline network for the Don Valley and the White Rose CCS projects, representing the possibilities in the Humber area. A model of the pipeline network was developed using the computer software package Aspen HYSYS® and three different operating strategies were compared and discussed regarding their energy and utilities requirement. For all three operating strategies, simulation results show that energy consumption ranges from 96 to 103 kWh/t-CO2 and cooling duty range from about 140 to 147 Mcal/t-CO2 in a wide range of the flow rate of the CO2-rich stream.