Pipelines are acknowledged as one of the most efficient and cost-effective methods for transporting large volumes of various fluids over long distances and therefore the majority of proposed schemes for Carbon Capture and Storage (CCS) involve high pressure pipelines transporting CO2. In order to manage the risk in the event of the failure of a carbon dioxide (CO2) pipeline, it is a core requirement that a separation distance between pipelines and habitable dwellings is defined to ensure a consistent level of risk. For natural gas pipelines, existing and accepted Quantitative Risk Assessment (QRA) techniques can be implemented to define safety zones based on the thermal hazards. However for CO2 pipelines, for which the hazard is toxic, the consequences of failure need to be considered differently as they relate to the toxic dosage that an individual receives during the release event. In addition, the dose received by the individual, in the unlikely event of a pipeline rupture, is dependent on the location of the individual during the event. The aim of this project is to develop validated and computationally efficient shelter and escape models describing the consequences to the surrounding population of a CO2 release from CCS transportation infrastructure. The models will allow pipeline operators, regulators and standard setters to make informed and appropriate decisions regarding pipeline safety and emergency response.